top of page

Shengdar Q. Tsai, PhD

Dr. Tsai is an Assistant Member in the Department of Hematology at St. Jude Children’s Research Hospital. His lab’s research focuses on developing genome editing technologies for therapeutics, with a special interest in editing human HSCs for treatment of hemoglobinopathies such as sickle cell disease and T-cells for cancer immunotherapy. In 2020, he was chosen as one of the American Society for Gene and Cell Therapy Outstanding New Investigators.

His group has recently developed CHANGE-seq, a state-of-the-art, sensitive, unbiased, high-throughput method for defining the genome-wide activity of genome editors (Lazzarotto et al. Nature Biotechnology 2020). Previously, he has led the development of methods for high-throughput genome editing with TALENs (Reyon and Tsai et al. Nature Biotechnology 2012), CRISPR-Cas genome editors with improved specificity by dimerization (Tsai et al. Nature Biotechnology 2014), widely adopted methods to define the genome-wide specificity of CRISPR-Cas nucleases such as GUIDE-seq (Tsai and Zheng et al. Nature Biotechnology 2015) and CIRCLE-seq (Tsai et al. Nature Methods 2017 and Lazzarotto et al. Nature Protocols 2018).

 

Dr. Tsai completed a postdoctoral fellowship at Massachusetts General Hospital & Harvard Medical School, Ph.D. in Functional Genomics and M.S. in Bioinformatics from North Carolina State University, and B.S. from the University of Michigan.  

10001686-009_Tsai_edited.jpg
  • LinkedIn
  • Twitter

Tsai Lab Members

00202527-010_Jividen.jpg

Dreylan Hines

Researcher

00202527-010_Jividen.jpg

Nikolay Malinin

Senior Scientist

00202527-010_Jividen.jpg

Elizabeth Urbina

Researcher

00202527-010_Jividen.jpg

Kasey Jividen

Post-Doctoral Fellow

00202527-010_Jividen.jpg

Azusa Matsubara

Scientist

00202527-010_Jividen.jpg

Rachael Wood

Senior Researcher

00202527-010_Jividen.jpg

Varun Katta

Scientist

00202527-010_Jividen.jpg

Kiera O'Keefe

Graduate Student

Team

Tsai Lab Alumni

Abby Cozart

Researcher (2020 - 2022)

PhD Student at University of Colorado Anshutz Medical

Michelle Lee

Researcher (2019 - 2021)

PhD Student at Northwestern

Tiffany Yee

Researcher (2019 - 2021)

PhD Student at UT Southwestern

Andrea Lee

Graduate Student

Cicera Lazzarotto

Scientist (2022)
Lead Researcher (2021-2022)
Senior Researcher (2019-2021)
Post-doctoral Fellow (2017-2019)

Senior Scientist at Beam Therapeutics

bottom of page