Shengdar Q. Tsai, PhD

Tsai_Photo.jpg
  • LinkedIn
  • Twitter

Dr. Tsai is an Assistant Member in the Department of Hematology at St. Jude Children’s Research Hospital. His lab’s research focuses on developing genome editing technologies for therapeutics, with a special interest in editing human HSCs for treatment of hemoglobinopathies such as sickle cell disease and T-cells for cancer immunotherapy. In 2020, he was chosen as one of the American Society for Gene and Cell Therapy Outstanding New Investigators.

His group has recently developed CHANGE-seq, a state-of-the-art, sensitive, unbiased, high-throughput method for defining the genome-wide activity of genome editors (Lazzarotto et al. Nature Biotechnology 2020). Previously, he has led the development of methods for high-throughput genome editing with TALENs (Reyon and Tsai et al. Nature Biotechnology 2012), CRISPR-Cas genome editors with improved specificity by dimerization (Tsai et al. Nature Biotechnology 2014), widely adopted methods to define the genome-wide specificity of CRISPR-Cas nucleases such as GUIDE-seq (Tsai and Zheng et al. Nature Biotechnology 2015) and CIRCLE-seq (Tsai et al. Nature Methods 2017 and Lazzarotto et al. Nature Protocols 2018).

 

Dr. Tsai completed a postdoctoral fellowship at Massachusetts General Hospital & Harvard Medical School, Ph.D. in Functional Genomics and M.S. in Bioinformatics from North Carolina State University, and B.S. from the University of Michigan.  

Meet the Team

00202527-010_Jividen.jpg

Abby Cozart

Research Technologist

00202527-010_Jividen.jpg

Cicera Lazzarotto

Post-doctoral Fellow

00202527-010_Jividen.jpg

Nikolay Malinin

Staff Scientist

00202527-010_Jividen.jpg

Kasey Jividen

Post-doctoral Fellow

00202527-010_Jividen.jpg

Andrea Lee

Graduate Student

00202527-010_Jividen.jpg

Kiera O'Keefe

Research Technologist

00202527-010_Jividen.jpg

Varun Katta

Research Lab Specialist

00202527-010_Jividen.jpg

Michelle Lee

Research Technologist

00202527-010_Jividen.jpg

Tiffany Yee

Research Technologist