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Shengdar Q. Tsai, PhD

Dr. Tsai is an Associate Member in the Department of Hematology at St. Jude Children’s Research Hospital. His lab’s research focuses on developing genome editing technologies for therapeutics, with a special interest in editing human HSCs for treatment of hemoglobinopathies such as sickle cell disease and T-cells for cancer immunotherapy. In 2020, he was chosen as one of the American Society for Gene and Cell Therapy Outstanding New Investigators.

His group has recently developed CHANGE-seq, a state-of-the-art, sensitive, unbiased, high-throughput method for defining the genome-wide activity of genome editors (Lazzarotto et al. Nature Biotechnology 2020). Previously, he has led the development of methods for high-throughput genome editing with TALENs (Reyon and Tsai et al. Nature Biotechnology 2012), CRISPR-Cas genome editors with improved specificity by dimerization (Tsai et al. Nature Biotechnology 2014), widely adopted methods to define the genome-wide specificity of CRISPR-Cas nucleases such as GUIDE-seq (Tsai and Zheng et al. Nature Biotechnology 2015) and CIRCLE-seq (Tsai et al. Nature Methods 2017 and Lazzarotto et al. Nature Protocols 2018).

 

Dr. Tsai completed a postdoctoral fellowship at Massachusetts General Hospital & Harvard Medical School, Ph.D. in Functional Genomics and M.S. in Bioinformatics from North Carolina State University, and B.S. from the University of Michigan.  

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shengdar.tsai at stjude.org

Tsai Lab Members

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Ashley Flory

Lead Researcher

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Kasey Jividen

Post-doctoral Fellow

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Garret Manquen

Researcher

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Joe Slaiwa

Senior Researcher

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Rachael Wood

Senior Researcher

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Claire Greene

Researcher

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Varun Katta

Scientist

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Azusa Matsubara

Scientist

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Despoina Trasanidou

Post-doctoral Fellow

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Dreylan Hines

Researcher

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Nikolay Malinin

Senior Scientist

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Kiera O'Keefe

Graduate Student

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Elizabeth Urbina

Researcher

Team

Tsai Lab Alumni

Abby Cozart

Researcher (2020 - 2022)

PhD Student at University of Colorado Anshutz Medical

Tiffany Yee

Researcher (2019 - 2021)

PhD Student at UT Southwestern

Cicera Lazzarotto

Scientist (2022)
Lead Researcher (2021-2022)
Senior Researcher (2019-2021)
Post-doctoral Fellow (2017-2019)

Senior Scientist at Beam Therapeutics

Michelle Lee

Researcher (2019 - 2021)

PhD Student at Northwestern

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